Publications

2022

Saha A, Capowski E, Fernandez Zepeda MA, Nelson EC, Gamm DM, Sinha R. Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea. Cell Stem Cell. 2022 Jan 25:S1934-5909(22)00002-9. doi: 10.1016/j.stem.2022.01.002. Online ahead of print. PMID: 35104442

2021

Courtney KC, Vevea JD, Li Y, Wu Z, Zhang Z, Chapman ER. Synaptotagmin 1 oligomerization via the juxtamembrane linker regulates spontaneous and evoked neurotransmitter release. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2113859118. doi: 10.1073/pnas.2113859118.PMID: 34810248

Kim JH, Lee HN, Huang X, Jung H, Otegui MS, Li F, Chung T. FYVE2, a phosphatidylinositol 3-phosphate effector, interacts with the COPII machinery to control autophagosome formation in Arabidopsis. Plant Cell. 2021 Oct 30:koab263. doi: 10.1093/plcell/koab263. Online ahead of print.PMID: 34718777

Laha K, Zhu M, Gemperline E, Rau V, Li L, Fanselow MS, Lennertz R, Pearce RA. CPP impairs contextual learning at concentrations below those that block pyramidal neuron NMDARs and LTP in the CA1 region of the hippocampus. Neuropharmacology. 2021 Oct 20;202:108846. doi: 10.1016/j.neuropharm.2021.108846. Online ahead of print.PMID: 34687710

Sinha R, Grimes WN, Wallin J, Ebbinghaus BN, Luu K, Cherry T, Rieke F, Rudolph U, Wong RO, Hoon M. Transient expression of a GABA receptor subunit during early development is critical for inhibitory synapse maturation and function. Curr Biol. 2021 Oct 11;31(19):4314-4326.e5. doi: 10.1016/j.cub.2021.07.059. Epub 2021 Aug 24.PMID: 34433078

Kunkel D, Parker M, Casey C, Krause B, Pearce RA, Lennertz R, Sanders RD. Impact of postoperative delirium on days alive and at home after surgery: a prospective cohort study. Br J Anaesth. 2021 Dec;127(6):e205-e207. doi: 10.1016/j.bja.2021.08.027. Epub 2021 Sep 29.PMID: 34598782

Figueroa AG, Benkwitz C, Surges G, Kunz N, Homanics GE, Pearce RA. Hippocampal β2-GABA_A receptors mediate LTP suppression by etomidate and contribute to long-lasting feedback but not feedforward inhibition of pyramidal neurons. J Neurophysiol. 2021 Oct 1;126(4):1090-1100. doi: 10.1152/jn.00303.2021. Epub 2021 Aug 18.PMID: 34406874

Vevea JD, Kusick GF, Courtney KC, Chen E, Watanabe S, Chapman ER. Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons. Elife. 2021 Sep 20;10:e67261. doi: 10.7554/eLife.67261.PMID: 34543184

Parker M, White M, Casey C, Kunkel D, Bo A, Blennow K, Zetterberg H, Pearce RA, Lennertz R, Sanders RD. Cohort Analysis of the Association of Delirium Severity with Cerebrospinal Fluid Amyloid-Tau-Neurodegeneration Pathologies. J Gerontol A Biol Sci Med Sci. 2021 Jul 14:glab203. doi: 10.1093/gerona/glab203. Online ahead of print.PMID: 34260706

Ma Y, Bayguinov PO, McMahon SM, Scharfman HE, Jackson MB. Direct synaptic excitation between hilar mossy cells revealed with a targeted voltage sensor. Hippocampus. 2021 Nov;31(11):1215-1232. doi: 10.1002/hipo.23386. Epub 2021 Sep 3.PMID: 34478219

Keen KL, Petersen AJ, Figueroa AG, Fordyce BI, Shin J, Yadav R, Erdin S, Pearce RA, Talkowski ME, Bhattacharyya A, Terasawa E. Physiological Characterization and Transcriptomic Properties of GnRH Neurons Derived From Human Stem Cells. Endocrinology. 2021 Sep 1;162(9):bqab120. doi: 10.1210/endocr/bqab120.PMID: 34125902

Goodman K, Paez-Valencia J, Pennington J, Sonntag A, Ding X, Lee HN, Ahlquist PG, Molina I, Otegui MS. ESCRT components ISTL1 andLIP5 are required for tapetal function and pollen viability. Plant Cell. 2021 Aug 31;33(8):2850-2868. doi: 10.1093/plcell/koab132.PMID: 34125207

Dorone Y, Boeynaems S, Flores E, Jin B, Hateley S, Bossi F, Lazarus E, Pennington JG, Michiels E, De Decker M, Vints K, Baatsen P, Bassel GW, Otegui MS, Holehouse AS, Exposito-Alonso M, Sukenik S, Gitler AD, Rhee SY. A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation. Cell. 2021 Aug 5;184(16):4284-4298.e27. doi: 10.1016/j.cell.2021.06.009. Epub 2021 Jul 6.PMID: 34233164

White MF, Tanabe S, Casey C, Parker M, Bo A, Kunkel D, Nair V, Pearce RA, Lennertz R, Prabhakaran V, Lindroth H, Sanders RD. Relationships between preoperative cortical thickness, postoperative electroencephalogram slowing, and postoperative delirium. Br J Anaesth. 2021 Aug;127(2):236-244. doi: 10.1016/j.bja.2021.02.028. Epub 2021 Apr 15.PMID: 33865555

Yanagisawa M, Poitout A, Otegui MS. Arabidopsis vascular complexity and connectivity controls PIN-FORMED1 dynamics and lateral vein patterning during embryogenesis. Development. 2021 Jul 1;148(14):dev197210. doi: 10.1242/dev.197210. Epub 2021 Jul 12.PMID: 34137447

Ding X, Zhang X, Olsen OA, Otegui MS. Transient expression of fluorescently tagged proteins in developing maize aleurone cells. MethodsX. 2021 Jul 7;8:101446. doi: 10.1016/j.mex.2021.101446. eCollection 2021.PMID: 34430333

Liu C, Zeng Y, Li H, Yang C, Shen W, Xu M, Xiao Z, Chen T, Li B, Cao W, Jiang L, Otegui MS, Gao C. A plant-unique ESCRT component, FYVE4, regulates multivesicular endosome biogenesis and plant growth. New Phytol. 2021 Jul;231(1):193-209. doi: 10.1111/nph.17358. Epub 2021 Apr 22.PMID: 33772801

Mandal T, Spagnolie SE, Audhya A, Cui Q. Protein-induced membrane curvature in coarse-grained simulations. Biophys J. 2021 Aug 3;120(15):3211-3221. doi: 10.1016/j.bpj.2021.05.029. Epub 2021 Jun 29.PMID: 34197798

Chiang CW, Shu WC, Wan J, Weaver BA, Jackson MB. Recordings from neuron-HEK cell cocultures reveal the determinants of miniature excitatory postsynaptic currents. J Gen Physiol. 2021 May 3;153(5):e202012849. doi: 10.1085/jgp.202012849.PMID: 33755721.

Nagy J, Ebbinghaus B, Hoon M, Sinha R. GABA_A presynaptic inhibition regulates the gain and kinetics of retinal output neurons. Elife. 2021 Apr 27;10:e60994. doi: 10.7554/eLife.60994.PMID: 33904401

Sawant A, Ebbinghaus BN, Bleckert A, Gamlin C, Yu WQ, Berson D, Rudolph U, Sinha R, Hoon M. Organization and emergence of a mixed GABA-glycine retinal circuit that provides inhibition to mouse ON-sustained alpha retinal ganglion cells. Cell Rep. 2021 Mar 16;34(11):108858. doi: 10.1016/j.celrep.2021.108858. PMID: 33730586

Chang CW, Hsiao YT, Jackson MB. Synaptophysin Regulates Fusion Pores and Exocytosis Mode in Chromaffin Cells. J Neurosci. 2021 Mar 4:JN-RM-2833-20. doi: 10.1523/JNEUROSCI.2833-20.2021. Online ahead of print. PMID: 33664131

Zhao M, Zhang F, Zarnowski R, Barns K, Jones R, Fossen J, Sanchez H, Rajski SR, Audhya A, Bugni TS, Andes DR. Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle-mediated trafficking. J Clin Invest. 2021 Mar 1;131(5):e145123. doi: 10.1172/JCI145123. PMID: 33373326

Wu L, Courtney KC, Chapman ER. Cholesterol stabilizes recombinant exocytic fusion pores by altering membrane bending rigidity. Biophys J. 2021 Feb 12:S0006-3495(21)00139-9. doi: 10.1016/j.bpj.2021.02.005. Online ahead of print. PMID: 33582136

Ballweg T, White M, Parker M, Casey C, Bo A, Farahbakhsh Z, Kayser A, Blair A, Lindroth H, Pearce RA, Blennow K, Zetterberg H, Lennertz R, Sanders RD. Association between plasma tau and postoperative delirium incidence and severity: a prospective observational study. Br J Anaesth. 2021 Feb;126(2):458-466. doi: 10.1016/j.bja.2020.08.061. Epub 2020 Nov 20. PMID: 33228978

Dieterich IA, Cui Y, Braun MM, Lawton AJ, Robinson NH, Peotter JL, Yu Q, Casler JC, Glick BS, Audhya A, Denu JM, Li L, Puglielli L. Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway. Sci Rep. 2021 Jan 21;11(1):2013. doi: 10.1038/s41598-021-81447-6. PMID: 33479349

Otegui MS. High-Pressure Freezing and Freeze Substitution for Transmission Electron Microscopy Imaging and Immunogold-Labeling. Methods Mol Biol. 2021;2200:337-347. doi: 10.1007/978-1-0716-0880-7_16. PMID: 33175386

2020

Jackson MB. Hebbian and non-Hebbian timing-dependent plasticity in the hippocampal CA3 region. Hippocampus. 2020 Dec;30(12):1241-1256. doi: 10.1002/hipo.23252. Epub 2020 Aug 20. PMID: 32818312

Lor C, Perouansky M, Pearce RA. Isoflurane Potentiation of GABA_A Receptors Is Reduced but Not Eliminated by the β3(N265M) Mutation. Int J Mol Sci. 2020 Dec 15;21(24):9534. doi: 10.3390/ijms21249534.

Zhang F, Zhao M, Braun DR, Ericksen SS, Piotrowski JS, Nelson J, Peng J, Ananiev GE, Chanana S, Barns K, Fossen J, Sanchez H, Chevrette MG, Guzei IA, Zhao C, Guo L, Tang W, Currie CR, Rajski SR, Audhya A, Andes DR, Bugni TS. A marine microbiome antifungal targets urgent-threat drug-resistant fungi. Science. 2020 Nov 20;370(6519):974-978. doi: 10.1126/science.abd6919. PMID: 33214279

Sanders RD, Craigova L, Schessler B, Casey C, White M, Parker M, Kunkel D, Blennow K, Zetterberg H, Pearce RA, Lennertz R. Postoperative troponin increases after noncardiac surgery are associated with raised neurofilament light: a prospective observational cohort study. Br J Anaesth. 2020 Nov 3:S0007-0912(20)30846-1. doi: 10.1016/j.bja.2020.10.012. Online ahead of print. PMID: 33158499

Maddox JW, Randall KL, Yadav RP, Williams B, Hagen J, Derr PJ, Kerov V, Della Santina L, Baker SA, Artemyev N, Hoon M, Lee A. A dual role for Ca_v1.4 Ca²⁺ channels in the molecular and structural organization of the rod photoreceptor synapse. Elife. 2020 Sep 17;9:e62184. doi: 10.7554/eLife.62184. PMID: 32940604

Zhang Z, Chapman ER. Programmable Nanodisc Patterning by DNA Origami. Nano Lett. 2020 Jul 15. doi: 10.1021/acs.nanolett.0c02048. Online ahead of print. PMID: 32648765

Jackson MB, Hsiao YT, Chang CW. Fusion Pore Expansion and Contraction during Catecholamine Release from Endocrine Cells. Biophys J. 2020 Jul 7;119(1):219-231. doi: 10.1016/j.bpj.2020.06.001. PMID: 32562620

Paez-Valencia J, Otegui MS. Cell-Free Protein Translation System for Expression of Lipid-Binding Proteins Tagged with Small epitopes and Their Use in Protein-Lipid Overlay Assays. Methods Mol Biol. 2020;2177:143-152. doi: 10.1007/978-1-0716-0767-1_12. PMID: 32632811

Czymmek K, Sawant A, Goodman K, Pennington J, Pedersen P, Hoon M, Otegui MS. Imaging Plant Cells by High-Pressure Freezing and Serial block-face scanning electron microscopy. Methods Mol Biol. 2020;2177:69-81. doi: 10.1007/978-1-0716-0767-1_7. PMID: 32632806

Otegui MS. Electron Tomography and Immunogold Labeling as Tools to Analyze De Novo Assembly of Plant Cell Walls. Methods Mol Biol. 2020;2149:365-382. doi: 10.1007/978-1-0716-0621-6_21. PMID: 32617946

Vevea JD, Chapman ER. Acute Disruption of the Synaptic Vesicle Membrane Protein Synaptotagmin 1 Using Knockoff in Mouse Hippocampal Neurons. Elife.2020 Jun 9;9;e56469. doi: 10.7554/eLife.56469. PMID: 32515733

Penfield L, Shankar R, Szentgyörgyi E, Laffitte A, Mauro MS, Audhya A, Müller-Reichert T, Bahmanyar S. Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure. J Cell Biol. 2020 May 4;219(5):e201908179. doi: 10.1083/jcb.201908179. PMID: 32271860

Bradberry MM, Courtney NA, Dominguez MJ, Lofquist SM, Knox AT, Sutton RB, Chapman ER. Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder. Neuron. 2020 Apr 21. pii: S0896-6273(20)30272-5. doi: 10.1016/j.neuron.2020.04.003. Epub 2020 May 1. PMID: 32362337

Mandal T, Lough W, Spagnolie SE, Audhya A, Cui Q. Molecular Simulation of Mechanical Properties and Membrane Activities of the ESCRT-III Complexes. Biophys J. 2020 Mar 24;118(6):1333-1343. doi: 10.1016/j.bpj.2020.01.033. Epub 2020 Feb 4. PMID: 32078797

Sinha R, Siddiqui TJ, Padmanabhan N, Wallin J, Zhang C, Karimi B, Rieke F, Craig AM, Wong RO, Hoon M. LRRTM4: A Novel Regulator of Presynaptic Inhibition and Ribbon Synapse Arrangements of Retinal Bipolar Cells. Neuron. 2020 Mar 18;105(6):1007-1017.e5. doi: 10.1016/j.neuron.2019.12.028. PMID: 31974009

Sinha R. Shining Light on the Mode and Mechanism of Vesicular Release at Rod Photoreceptor Synapse. Biophys J. 2020 Feb 25;118(4):785-787. doi: 10.1016/j.bpj.2019.12.009. Epub 2019 Dec 18. PMID: 32101707

Zhang X, Ding X, Marshall RS, Paez-Valencia J, Lacey P, Vierstra RD, Otegui MS. Reticulon Proteins Modulate Autophagy of the Endoplasmic Reticulum in Maize Endosperm. Elife. 2020 Feb 3;9:e51918. doi: 10.7554/eLife.51918. PMID: 32011236

Das D, Bao H, Courtney KC, Wu L, Chapman ER. Resolving Kinetic Intermediates During the Regulated Assembly and Disassembly of Fusion Pores. Nat Commun. 2020 Jan 13;11(1):231. doi: 10.1038/s41467-019-14072-7. PMID: 31932584

2019

Ma Y, Bayguinov PO, Jackson MB. Optical Studies of Action Potential Dynamics with hVOS probes. Curr Opin Biomed Eng. 2019 Dec;12:51-58. doi: 10.1016/j.cobme.2019.09.007. Epub 2019 Sep 23. PMID: 32864524

Block S, Schuh AL, Audhya A. Biochemical Approaches to Studying Caenorhabditis elegans ESCRT Functions In Vitro. Methods Mol Biol. 2019;1998:189-202. doi: 10.1007/978-1-4939-9492-2_14. PMID: 31250303

Courtney NA, Bao H, Briguglio JS, Chapman ER. Synaptotagmin 1 Clamps Synaptic Vesicle Fusion in Mammalian Neurons Independent of Complexin. Nat Commun. 2019 Sep 9;10(1):4076. doi: 10.1038/s41467-019-12015-w. PMID: 31501440.

Ruhl DA, Bomba-Warczak E, Watson ET, Bradberry MM, Peterson TA, Basu T, Frelka A, Evans CS, Briguglio JS, Basta T, Stowell MHB, Savas JN, Roopra A, Pearce RA, Piper RC, Chapman ER. Synaptotagmin 17 Controls Neurite Outgrowth and Synaptic Physiology via Distinct Cellular Pathways. Nat Commun. 2019 Aug 6;10(1):3532. doi: 10.1038/s41467-019-11459-4. PMID: 31387992.

Brose N, Brunger A, Cafiso D, Chapman ER, Diao J, Hughson FM, Jackson MB, Jahn R, Lindau M, Ma C, Rizo J, Shin YK, Söllner TH, Tamm L, Yoon TY, Zhang Y. Synaptic Vesicle Fusion: Today and Beyond. Nat Struct Mol Biol. 2019 Aug;26(8):663-668. doi: 10.1038/s41594-019-0277-z. PMID: 31384060.

Bradberry MM, Bao H, Lou X, Chapman ER. Phosphatidylinositol 4,5-bisphosphate Drives Ca 2+-independent Membrane Penetration by the Tandem C2 Domain Proteins synaptotagmin-1 and Doc2β. J Biol Chem. 2019 Jul 12;294(28):10942-10953. doi: 10.1074/jbc.RA119.007929. Epub 2019 May 30. PMID: 31147445.

Peotter J, Kasberg W, Pustova I, Audhya A. COPII-mediated Trafficking at the ER/ERGIC Interface. Traffic. 2019 Jul;20(7):491-503. doi: 10.1111/tra.12654. Epub 2019 May 30. PMID: 31059169.

Quinney KB, Frankel EB, Shankar R, Kasberg W, Luong P, Audhya A. Growth Factor Stimulation Promotes Multivesicular Endosome Biogenesis by Prolonging Recruitment of the Late-Acting ESCRT Machinery. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6858-6867. doi: 10.1073/pnas.1817898116. Epub 2019 Mar 20. PMID: 30894482.

Perouansky M, MacIver MB, Pearce RA. Wake Up, Neurons! Astrocytes Calling. Anesthesiology. 2019 Mar;130(3):361-363. doi: 10.1097/ALN.0000000000002589. PMID: 30707121.

Mineyuki Y, Otegui MS. For Microscopy Special Issue on ‘Plant Science’. Microscopy (Oxf). 2019 Feb 1;68(1):3. doi: 10.1093/jmicro/dfz006. PMID: 31373626.

Paez-Valencia J, Otegui MS. Purification of Plant ESCRT Proteins for Polyclonal Antibody Production. Methods Mol Biol. 2019;1998:227-238. doi: 10.1007/978-1-4939-9492-2_17. PMID: 31250306.